Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 2.783


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSL1chr11_-_656678090.873.7e-10Click!
FOSchr14_+_757454800.861.0e-09Click!
FOSBchr19_+_459712490.641.4e-04Click!
JUNBchr19_+_129022950.622.6e-04Click!
JUNDchr19_-_183924130.431.7e-02Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_36019194 25.410 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr19_-_51472816 25.000 NM_002774
KLK6
kallikrein-related peptidase 6
chr18_+_21452981 24.895 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_183155173 23.820 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr12_+_13349601 22.948 NM_001423
EMP1
epithelial membrane protein 1
chr12_+_13349720 22.675 EMP1
epithelial membrane protein 1
chr1_-_153029987 22.470 NM_005988
SPRR2A
small proline-rich protein 2A
chr6_+_47666288 21.557 NM_153838
GPR115
G protein-coupled receptor 115
chr1_-_153013593 21.419 NM_006945
SPRR2D
small proline-rich protein 2D
chr1_+_183155361 18.405 LAMC2
laminin, gamma 2
chr1_+_183155393 17.299 LAMC2
laminin, gamma 2
chr1_+_150480486 17.275 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr1_+_150480584 16.737 ECM1
extracellular matrix protein 1
chr1_-_153521717 15.509 NM_002960
S100A3
S100 calcium binding protein A3
chr1_-_153067000 14.720 NM_001024209
SPRR2E
small proline-rich protein 2E
chr21_+_30517897 13.941 C21orf7
chromosome 21 open reading frame 7
chr19_+_35645640 13.361 NM_144779
NM_001164605
FXYD5

FXYD domain containing ion transport regulator 5

chr10_+_17270469 13.164 VIM
vimentin
chr2_-_216259197 12.650 FN1
fibronectin 1
chr1_+_152486977 12.261 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr10_+_17270257 11.948 NM_003380
VIM
vimentin
chr7_+_48128225 11.903 NM_181597
UPP1
uridine phosphorylase 1
chr13_+_78109808 11.810 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr19_+_35645614 11.752 NM_014164
FXYD5
FXYD domain containing ion transport regulator 5
chr1_+_152956563 11.725 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr17_-_39768939 11.557 NM_005557
KRT16
keratin 16
chr11_-_65667858 11.217 FOSL1
FOS-like antigen 1
chrX_+_99899162 10.946 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr21_+_41029253 10.838 NM_006057
NM_033170
NM_033171
NM_033172
NM_033173
B3GALT5




UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5




chr2_+_113875469 10.799 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr1_+_32043745 10.637 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_152881022 10.509 NM_005547
IVL
involucrin
chrX_+_99899388 10.461 SRPX2
sushi-repeat containing protein, X-linked 2
chr10_+_118187381 10.047 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr18_+_61442611 9.795 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr13_-_60325073 9.664


chr8_+_7752198 9.421 NM_004942
DEFB4A
defensin, beta 4A
chr19_-_44285407 9.370 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_+_153003677 9.214 NM_003125
SPRR1B
small proline-rich protein 1B
chr20_+_33759773 9.030 NM_006404
PROCR
protein C receptor, endothelial
chr19_-_51523272 9.018 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr6_+_74405764 8.991 CD109
CD109 molecule
chr17_+_74381186 8.957 NM_001142602
SPHK1
sphingosine kinase 1
chrX_+_135251795 8.738 NM_001167819
FHL1
four and a half LIM domains 1
chr17_+_74381419 8.552 SPHK1
sphingosine kinase 1
chr11_-_65667860 8.390 NM_005438
FOSL1
FOS-like antigen 1
chr6_+_74405505 8.383 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr19_+_35646006 8.309 FXYD5
FXYD domain containing ion transport regulator 5
chr2_-_65593866 8.115 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr17_+_74380943 8.010 SPHK1
sphingosine kinase 1
chr9_+_35673852 7.989 NM_001216
CA9
carbonic anhydrase IX
chr11_-_65667809 7.875 FOSL1
FOS-like antigen 1
chr1_-_162381805 7.860 NM_053282
SH2D1B
SH2 domain containing 1B
chr15_-_56209305 7.689 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr6_+_74405909 7.667 CD109
CD109 molecule
chr16_-_30124829 7.516 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr12_-_54813002 7.477 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr11_-_102668822 7.301 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr11_-_102668892 7.283 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr12_+_107974633 7.107 NM_001017523
BTBD11
BTB (POZ) domain containing 11
chr9_+_140119643 6.909 NM_199001
C9orf169
chromosome 9 open reading frame 169
chr6_+_74405933 6.903 CD109
CD109 molecule
chr10_-_76868853 6.818 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr1_+_153232178 6.814 NM_000427
LOR
loricrin
chr11_-_6341708 6.772 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr1_-_179112178 6.719 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr9_-_139890984 6.710 NM_004669
CLIC3
chloride intracellular channel 3
chr4_-_159092509 6.699 FAM198B
family with sequence similarity 198, member B
chr3_-_149095413 6.636 TM4SF1
transmembrane 4 L six family member 1
chr4_-_39033981 6.508 NM_024943
TMEM156
transmembrane protein 156
chr7_-_107643330 6.409 NM_002291
LAMB1
laminin, beta 1
chr19_-_39264144 6.371 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr3_-_149095517 6.351 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr19_-_44285012 6.308 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_-_204120909 6.283 ETNK2
ethanolamine kinase 2
chr3_-_48632592 6.248 NM_000094
COL7A1
collagen, type VII, alpha 1
chr17_-_33390676 6.227 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr3_-_149095458 6.185 TM4SF1
transmembrane 4 L six family member 1
chr8_-_125580745 6.101 MTSS1
metastasis suppressor 1
chr19_-_19051112 6.051 NM_001145722
NM_001145721
HOMER3

homer homolog 3 (Drosophila)

chr6_+_74405856 6.006 CD109
CD109 molecule
chr10_-_90611675 5.989 NM_144590
ANKRD22
ankyrin repeat domain 22
chr12_-_54812936 5.926 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr1_-_28520379 5.885 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr3_-_149095333 5.852 TM4SF1
transmembrane 4 L six family member 1
chr1_+_152974222 5.848 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr9_-_99064385 5.826 NM_000197
HSD17B3
hydroxysteroid (17-beta) dehydrogenase 3
chr2_-_65593763 5.713 SPRED2
sprouty-related, EVH1 domain containing 2
chr9_+_33795558 5.614 NM_002771
PRSS3
protease, serine, 3
chr20_-_1309809 5.606 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr19_-_51537996 5.529 NM_019598
NM_145894
NM_145895
KLK12


kallikrein-related peptidase 12


chr7_-_50772997 5.401 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr11_-_102826433 5.380 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr17_-_7493389 5.335 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr1_-_244006471 5.307 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr19_-_35992798 5.303 NM_001035516
DMKN
dermokine
chr11_+_394238 5.266 PKP3
plakophilin 3
chr9_+_103191795 5.188 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr19_-_36004553 5.157 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr1_+_24645914 5.134 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr10_+_82173574 4.994 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr16_-_28518131 4.936 NM_145659
IL27
interleukin 27
chr11_+_394199 4.921 NM_007183
PKP3
plakophilin 3
chr16_+_58534045 4.876 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chrX_+_51075082 4.827 NM_153183
NUDT10
nudix (nucleoside diphosphate linked moiety X)-type motif 10
chr1_+_24645811 4.825 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr2_-_85641128 4.784 CAPG
capping protein (actin filament), gelsolin-like
chr2_-_85641153 4.768 CAPG
capping protein (actin filament), gelsolin-like
chr1_+_17531619 4.731 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr2_-_72374919 4.684 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr9_-_130341265 4.602 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr6_-_35696359 4.595 NM_001145775
FKBP5
FK506 binding protein 5
chr1_-_154943001 4.589 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr1_-_204121144 4.565 NM_018208
ETNK2
ethanolamine kinase 2
chr3_-_98241357 4.535 CLDND1
claudin domain containing 1
chr2_+_28615771 4.531 NM_005253
FOSL2
FOS-like antigen 2
chr8_-_42623928 4.413 NM_001199279
NM_004198
CHRNA6

cholinergic receptor, nicotinic, alpha 6

chr15_+_89182038 4.406 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr11_-_118134956 4.390 MPZL2
myelin protein zero-like 2
chr11_+_62649160 4.379 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr9_+_4985082 4.379 JAK2
Janus kinase 2
chr12_-_54813010 4.355 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr5_-_39203061 4.355 FYB
FYN binding protein
chr2_+_33359607 4.333 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr5_-_140013034 4.332 NM_000591
CD14
CD14 molecule
chr4_+_74606222 4.317 NM_000584
IL8
interleukin 8
chr5_-_140012730 4.200 CD14
CD14 molecule
chr2_+_28615695 4.194 FOSL2
FOS-like antigen 2
chr1_+_209878135 4.189 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr15_+_59397276 4.160 NM_004701
CCNB2
cyclin B2
chr6_+_106546736 4.158 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr7_+_26400503 4.131 NM_001199837
SNX10
sorting nexin 10
chr21_-_31869427 4.126 NM_181610
KRTAP19-4
keratin associated protein 19-4
chr17_+_73717596 4.024 ITGB4
integrin, beta 4
chr17_+_73717556 3.992 ITGB4
integrin, beta 4
chr5_-_140013285 3.991 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr8_+_22844918 3.971 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr2_+_169926084 3.963 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_+_171154387 3.957 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr11_+_12308446 3.942 NM_032867
MICALCL
MICAL C-terminal like
chr20_+_44637539 3.890 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr1_-_24469571 3.864 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr19_-_44174497 3.863 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr2_-_85637486 3.852 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr11_+_72983246 3.847 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr17_+_73717515 3.835 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr7_+_134212343 3.828 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr11_+_706607 3.820 EPS8L2
EPS8-like 2
chr9_+_4985243 3.783 NM_004972
JAK2
Janus kinase 2
chr19_-_51512803 3.733 NM_012315
KLK9
kallikrein-related peptidase 9
chr7_+_143078457 3.726 ZYX
zyxin
chr19_+_39279849 3.691 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr18_+_21693316 3.691 TTC39C
tetratricopeptide repeat domain 39C
chr6_-_152702329 3.664 SYNE1
spectrin repeat containing, nuclear envelope 1
chr11_-_2193015 3.652 NM_000360
NM_199292
NM_199293
TH


tyrosine hydroxylase


chrX_+_135251454 3.645 NM_001159704
FHL1
four and a half LIM domains 1
chr2_+_87755059 3.641 LINC00152
long intergenic non-protein coding RNA 152
chr4_+_169013687 3.612 NM_007193
ANXA10
annexin A10
chr1_-_17308072 3.605 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr2_+_87754991 3.591 LINC00152
long intergenic non-protein coding RNA 152
chr10_+_5238756 3.578 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr7_+_143078399 3.575 ZYX
zyxin
chr20_-_6104056 3.552 NM_017671
FERMT1
fermitin family member 1
chr11_-_2162340 3.549 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr7_+_26331611 3.533 SNX10
sorting nexin 10
chr17_-_9694613 3.520 NM_001105571
NM_001220493
DHRS7C

dehydrogenase/reductase (SDR family) member 7C

chr4_+_84457256 3.471 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr1_-_27816667 3.466 WASF2
WAS protein family, member 2
chr7_+_143078395 3.456 ZYX
zyxin
chr17_+_16945766 3.453 NM_015134
NM_201274
MPRIP

myosin phosphatase Rho interacting protein

chr7_+_143078444 3.453 ZYX
zyxin
chr7_+_143078447 3.424 ZYX
zyxin
chr1_+_26606621 3.396 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr20_-_17539480 3.381 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr21_+_30452872 3.380 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr7_+_143078358 3.340 NM_001010972
NM_003461
ZYX

zyxin

chr12_-_49259549 3.311 NM_014470
RND1
Rho family GTPase 1
chr1_-_95007139 3.309 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr6_+_32121228 3.300 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr12_+_9142136 3.292 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr8_+_22210311 3.287 PIWIL2
piwi-like 2 (Drosophila)
chr2_-_85637473 3.284 CAPG
capping protein (actin filament), gelsolin-like
chr12_-_53625834 3.274 NM_000966
NM_001243730
NM_001243731
RARG


retinoic acid receptor, gamma


chr9_-_91267004 3.262 NM_001100111
LOC286238
uncharacterized LOC286238
chr19_+_925984 3.227 NM_005224
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr12_-_48152180 3.212 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr6_-_30655671 3.171 NM_133471
PPP1R18
protein phosphatase 1, regulatory subunit 18
chr1_+_44398991 3.171 NM_001136215
NM_057090
NM_057091
ARTN


artemin


chr7_+_128095881 3.164 NM_001098786
NM_013332
HILPDA

hypoxia inducible lipid droplet-associated

chr18_+_61554938 3.145 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr11_+_706103 3.132 NM_022772
EPS8L2
EPS8-like 2
chr2_+_202316391 3.101 NM_001206864
NM_018571
STRADB

STE20-related kinase adaptor beta

chr17_-_45928530 3.100 SP6
Sp6 transcription factor
chr1_-_209824641 3.096 NM_001017402
LAMB3
laminin, beta 3
chr7_+_134233848 3.091 NM_001080538
AKR1B15
aldo-keto reductase family 1, member B15
chr22_-_37584254 3.085 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr7_-_93519990 3.072 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr20_-_23030141 3.048 NM_000361
THBD
thrombomodulin
chr19_-_39235113 3.044 NM_144691
CAPN12
calpain 12
chr12_-_48152860 3.039 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.34 2.30e-05 GO:0007165 signal transduction
2.62 1.51e-04 GO:0008544 epidermis development
1.30 1.67e-04 GO:0023052 signaling
1.63 7.55e-04 GO:0032879 regulation of localization
1.26 1.92e-03 GO:0051716 cellular response to stimulus
1.64 2.02e-03 GO:0009611 response to wounding
1.35 3.02e-03 GO:0048522 positive regulation of cellular process
1.49 3.91e-03 GO:0035556 intracellular signal transduction
5.28 6.65e-03 GO:0032963 collagen metabolic process
1.29 9.00e-03 GO:0048856 anatomical structure development
1.31 9.88e-03 GO:0048518 positive regulation of biological process
1.18 1.14e-02 GO:0050896 response to stimulus
1.16 1.38e-02 GO:0050794 regulation of cellular process
1.73 1.40e-02 GO:0042060 wound healing
1.25 1.41e-02 GO:0032502 developmental process
4.93 1.47e-02 GO:0044259 multicellular organismal macromolecule metabolic process
1.75 1.52e-02 GO:0050878 regulation of body fluid levels
1.29 2.75e-02 GO:0048731 system development
1.26 2.92e-02 GO:0007275 multicellular organismal development
1.37 3.05e-02 GO:0048513 organ development
1.51 3.23e-02 GO:0010646 regulation of cell communication
1.76 4.65e-02 GO:0007599 hemostasis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.40 3.10e-04 GO:0001533 cornified envelope
1.62 7.67e-04 GO:0005626 insoluble fraction
1.48 5.41e-03 GO:0000267 cell fraction
1.55 1.02e-02 GO:0005624 membrane fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 2.02e-03 GO:0005515 protein binding